Naloxone Naloxone

Naloxone Naloxone

Classification of Martindel: Antibodies, Chelators, and Antagonists
Therapeutic classification: Drugs affecting the central nervous system> Opioid antagonists

Indications for naloxone

Naloxone is used to treat respiratory depression caused by opium-like drugs for the treatment of opioid poisoning, as well as as an adjunct in the treatment of septic shock.

Mechanism of action of naloxone

This drug blocks the micro-opioid receptor. In this way, it prevents the effects of opium-like drugs that are exerted by stimulating this receptor. (Including weakening of the respiratory center in the central nervous system).

Pharmacokinetics of naloxone

The onset of action of the drug is 2-5 minutes after intramuscular injection and 1-2 minutes after intravenous injection. The duration of action of this drug is 1-2 hours after injection. It is metabolized in the liver and its metabolites are excreted in the urine. The half-life of the drug is 64 minutes.
Side effects of naloxone
*
Other complications (unspecified percentage):

Cardiovascular: hot flush (injection), hypertension, hypotension, tachycardia, ventricular fibrillation, ventricular tachycardia
Central nervous system: agitation, body aches, brain disease, coma, confusion (injection), disorientation or position recognition disorder (injection), dizziness (injection), excessive crying of infants, hallucinations (injection), headache (intranasal) ), Neonatal hyperreflexia, irritability, anger, rage (injection), limb drowsiness (injection), restlessness, neonatal seizures, tremor, tonic-clonic seizures (injection), withdrawal syndrome, yawning
Skin: Increased sweating, hair skewering, dry mouth (inside the nose)
Endocrinology and Metabolism: Flushing (Injection)
Gastrointestinal: abdominal cramps, constipation (inside the nose), diarrhea, nausea, toothache (inside the nose), vomiting
Local: injection site erythema (injection), injection site reaction
Neuromuscular and musculoskeletal: muscle spasm (inside the nose), muscle and bone pain (inside the nose), tremor, weakness
Respiratory: dry nose (inside the nose), shortness of breath, hypoxia (injection), nasal congestion (inside the nose), nasal discomfort (pain; inside the nose), swelling of the nasal mucosa (inside the nose), pulmonary edema, respiratory depression (injection), Rhinitis (inside the nose), runny nose, sneezing
Miscellaneous: Fever