Triptorelin

Triptorelin

Uses of Triptorlin

Triptorelin is a Gonadorelin analogue with similar properties. It is used to suppress the production of sex hormones, in the treatment of malignant neoplasms of the prostate, in precocious puberty and in the treatment of endometriosis and infertility in women and uterine fibroids. It is available as a base, acetate, diacetate, or implant and is used.

Mechanism of action of tryptorulin

Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist that inhibits steroid production by the ovaries and testes, thereby lowering LH and FSH levels, followed by testosterone (in men) and estrogen (in women). ) it is decreasing. With chronic and continuous administration of tryptoruline, a continuous decrease in FSH and LH secretion usually occurs 2 to 4 weeks after the start of treatment. If used for ART, it prevents premature LH peak in women with controlled ovarian stimulation.

Pharmacokinetics of tryptoruline

Triptorelin is rapidly absorbed after subcutaneous injection, and peak plasma concentrations are reached within 40 minutes after a single dose. Its biological half-life is about 7.5 hours, although longer half-lives have been reported in patients with prostate cancer and shorter half-lives have been seen in some healthy individuals.

Contraindications to tryptorol

Hypersensitivity to tryptoruline and its components and other GnRH agonists, pregnancy and lactation